TRACHEAL SMOOTH MUSCLE RELAXANT EFFECT OF KETAMINE

TRACHEAL SMOOTH MUSCLE RELAXANT EFFECT OF KETAMINE

Ketamine is claimed to decrease airways resistance in patients suffering from broncho-constriction. Investigations of its mechanism of action were undertaken using the guineapig tracheal chain, a preparation which reacts to drugs in a manner similar to that of the smooth muscle of human bronchioles....

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Veröffentlicht in:British journal of anaesthesia : BJA 1974-05, Vol.46 (5), p.333-336
Hauptverfasser: LUNDY, P.M., GOWDEY, C.W., COLHOUN, E.H.
Format: Artikel
Sprache:eng
Schlagworte:
Airway Resistance - drug effects
Anesthesia, Intravenous
Animals
Carbachol - pharmacology
Dose-Response Relationship, Drug
Epinephrine - pharmacology
Guinea Pigs
Ketamine - pharmacology
Male
Muscle, Smooth - drug effects
Trachea - drug effects
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Zusammenfassung:Ketamine is claimed to decrease airways resistance in patients suffering from broncho-constriction. Investigations of its mechanism of action were undertaken using the guineapig tracheal chain, a preparation which reacts to drugs in a manner similar to that of the smooth muscle of human bronchioles. Ketamine was found to possess a direct relaxant effect on the tracheal chain, to antagonize the spasmogenic effects of carbachol and potentiate the antispasmodic effects of adrenaline. Reduction in airway resistance after ketamine anaesthesia is probably the result of a direct relaxant effect on bronchial smooth muscle and a changed response to endogenous humoral substances.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/46.5.333