Effect of ACTH and Insulin on AIB Accumulation in Diaphragm Muscle and Adrenal in vivo.

Summary Hypophysectomy causes a decline in accumulation of the amino acid analogue, α-aminoisobutyrate (AIB), in adrenal and diaphragm muscle of functionally nephrectomized rats. Either Corticotropin A or insulin increase AIB accumulation to an equivalent extent in adrenal of hypophysectomized rats; both hormones also increase AIB uptake in diaphragm muscle, but insulin is more effective in this tissue. The combined influence of these hormones on both tissues is greater than either alone. The significance of these observations for protein synthesis and growth in the adrenal are discussed.