Alterations in Sialic Acid Content of Human Transferrin

Alterations in Sialic Acid Content of Human Transferrin

Starch gel electrophoresis of human transferrin treated with neuraminidase revealed a pattern of five bands whose intensities varied with neuraminidase concentration. Sialic acid analysis after starch block electrophoresis suggested that the bands represented the stepwise removal of sialic acid from...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1961-03, Vol.133 (3457), p.1014-1016
Hauptverfasser: Parker, W. Carey, Bearn, Alexander G.
Format: Artikel
Sprache:eng
Schlagworte:
Blacksmithing
Electrophoresis
Enzymes
Gels
Genetic variation
Human genetics
Humans
Molecular genetics
Molecules
N-Acetylneuraminic Acid
Neuraminic Acids - chemistry
Neuraminidase
Old Medline
Starch
Starches
Transferrin - chemistry
Transferrins
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Zusammenfassung:Starch gel electrophoresis of human transferrin treated with neuraminidase revealed a pattern of five bands whose intensities varied with neuraminidase concentration. Sialic acid analysis after starch block electrophoresis suggested that the bands represented the stepwise removal of sialic acid from the transferrin molecule. Evidence was also obtained for the purification of a particular genetic transferrin variant.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.133.3457.1014