Applicability of Hydroxocobalamin as a Long-acting Vitamin B12

Applicability of Hydroxocobalamin as a Long-acting Vitamin B12

THE main difficulty in the treatment of vitamin B 12 deficiencies has been that small doses of cyanocobalamin are inadequate to replenish the body's depleted stores and that most of the large parenteral doses are eliminated in the urine within the first 12 hr.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1961-01, Vol.189 (4759), p.138-140
Hauptverfasser: GLASS, G. B. J., SKEGGS, H. R., LEE, D. H., JONES, E. L., HARDY, W. W.
Format: Artikel
Sprache:eng
Schlagworte:
Corrinoids
Humanities and Social Sciences
Humans
Hydroxocobalamin
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Vitamin A
Vitamin B 12 - pharmacology
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Beschreibung
Zusammenfassung:THE main difficulty in the treatment of vitamin B 12 deficiencies has been that small doses of cyanocobalamin are inadequate to replenish the body's depleted stores and that most of the large parenteral doses are eliminated in the urine within the first 12 hr.
ISSN:0028-0836
1476-4687
DOI:10.1038/189138b0