Ventral Medial Hypothalamus: Involvement in Hypoglycemic Convulsions

After the ventral medial hypothalamus of mice was lesioned with gold thioglucose, the dose of insulin required to produce convulsions in 50 percent of the animals was doubled compared to that in nonlesionad controls. No dose of insulin, up to 50 milliunits per gram, produced convulsions in more than...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1975-02, Vol.187 (4178), p.746-748
Hauptverfasser:	Kellar, Kenneth J., Langley, Albert E., Marks, Bernard H., O'Neill, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurothioglucose - pharmacology Blood glucose Convulsions Erythrocytes Fasting Hypoglycemia - physiopathology Hypoglycemic agents Hypothalamus Hypothalamus - drug effects Hypothalamus - physiopathology Insulin Insulin Coma - complications Insulin Coma - physiopathology Lesions Merozoites Parasites Seizures - etiology Seizures - physiopathology
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Beschreibung
Zusammenfassung:	After the ventral medial hypothalamus of mice was lesioned with gold thioglucose, the dose of insulin required to produce convulsions in 50 percent of the animals was doubled compared to that in nonlesionad controls. No dose of insulin, up to 50 milliunits per gram, produced convulsions in more than 60 percent of the lesioned mice, even though blood glucose levels fell to approximately 24 milligram percent.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.187.4178.746