Inhibition of enzymic hydrolysis of plasma albumin by detergents

Inhibition of enzymic hydrolysis of plasma albumin by detergents

Digestion of bovine plasma albumin by either trypsin or chymotrypsin is markedly diminished by sodium octyl sulfate, yet enzymic hydrolysis of simple substances is hardly affected by this detergent. Tryptic digestion of bovine albumin is similarly inhibited by sodium decyl and dodecyl sulfates, whil...

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Veröffentlicht in:Archives of biochemistry and biophysics 1961-06, Vol.93 (3), p.538-541
Hauptverfasser: Epstein, Samuel I., Possick, Paul A.
Format: Artikel
Sprache:eng
Schlagworte:
Detergents
Hydrolysis
Old Medline
Serum Albumin - chemistry
Surface-Active Agents - chemistry
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Zusammenfassung:Digestion of bovine plasma albumin by either trypsin or chymotrypsin is markedly diminished by sodium octyl sulfate, yet enzymic hydrolysis of simple substances is hardly affected by this detergent. Tryptic digestion of bovine albumin is similarly inhibited by sodium decyl and dodecyl sulfates, while digestion of α-globulin is nearly unaffected. Implications of the inhibition are discussed.
ISSN:0003-9861
1096-0384
DOI:10.1016/S0003-9861(61)80048-9