Effects of Para-Chlorophenylalanine on Pregnancy in the Rat
To test the hypothesis that 5-hydroxytryptamine (5HT) may play a role in the onset of parturition, rats were given p -chlorophenylalanine (PCPA), an inhibitor of 5HT synthesis, via gavage. PCPA administration greatly affected pregnant rats. High dosages of PCPA (316 mg/kg/day on alternate days) indu...
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Veröffentlicht in: | Biology of reproduction 1974-10, Vol.11 (3), p.280-287 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To test the hypothesis that 5-hydroxytryptamine (5HT) may play a role in the onset
of parturition, rats were given p -chlorophenylalanine (PCPA), an inhibitor of 5HT synthesis,
via gavage. PCPA administration greatly affected pregnant rats. High dosages of PCPA
(316 mg/kg/day on alternate days) induced total resorption between Days 12 and 15
and reduced maternal weight gain. Lower dosages of PCPA (158 mg/kg/day on Days
2, 4, 6, 8, 10, and 12 and 316 mg/kg/day on Days 14, 16, 18, 20, and 21) resulted
in partial resorption, reduced maternal and fetal weight gain, immediate neonatal death,
and cannibalism. 5HT was significantly reduced in maternal brain (97%), placentas (82%),
whole fetuses (96%), and uteri (69%). Maternal adrenal hypertrophy occurred only when
conceptuses were present. Because gestational length was not altered, we concluded that
5HT did not play a significant role in the onset of parturition. |
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ISSN: | 0006-3363 1529-7268 |
DOI: | 10.1095/biolreprod11.3.280 |