Immunotherapy of melanoma with BCG: Two fatalities following intralesional injection

Two fatalities are reported following intralesional injection of BCG for immuno‐therapy of malignant melanoma. In both cases the terminal events were characterized by high fevers, major clotting defects, hypotension, and anuria, suggesting that the mechanism was hypersensitivity to BCG.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer 1975-02, Vol.35 (2), p.514-520
Hauptverfasser:	McKhann, Charles F., Hendrickson, Charles G., Spitler, Lynn E., Gunnarsson, Audolfur, Banerjee, D., Nelson, William R.
Format:	Artikel
Sprache:	eng
Schlagworte:	BCG Vaccine - administration & dosage BCG Vaccine - adverse effects BCG Vaccine - therapeutic use Female Humans Hypersensitivity - etiology Immunotherapy - adverse effects Melanoma - therapy Middle Aged Neoplasm Metastasis Skin Neoplasms - therapy
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Beschreibung
Zusammenfassung:	Two fatalities are reported following intralesional injection of BCG for immuno‐therapy of malignant melanoma. In both cases the terminal events were characterized by high fevers, major clotting defects, hypotension, and anuria, suggesting that the mechanism was hypersensitivity to BCG.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(197502)35:2<514::AID-CNCR2820350233>3.0.CO;2-F