Inhibition of adenyl cyclase by an exotoxin of Bacillus thuringiensis

Inhibition of adenyl cyclase by an exotoxin of Bacillus thuringiensis

CERTAIN strains of the insect pathogen Bacillus thuringiensis produce a heat-stable exotoxin which is toxic to species from several orders of insects 1,2 and also affects mammals 3–5 . The exotoxin inhibits ecdysone-stimulated insect RNA polymeras of mice both in vivo 6 and in vitro 7 .

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1975-01, Vol.253 (5486), p.58-60
Hauptverfasser: GRAHAME-SMITH, D. G, ISAAC, P, HEAL, D. J, BOND, R. P. M
Format: Artikel
Sprache:eng
Schlagworte:
11-Hydroxycorticosteroids - biosynthesis
Adenosine Triphosphate - metabolism
Adenylyl Cyclase Inhibitors
Adenylyl Cyclases - blood
Adrenal Glands - enzymology
Animals
Bacillus
Brain - enzymology
Columbidae
Cyclic AMP - biosynthesis
Erythrocytes - enzymology
Humanities and Social Sciences
In Vitro Techniques
letter
Male
multidisciplinary
Rats
Science
Science (multidisciplinary)
Toxins, Biological - pharmacology
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Beschreibung
Zusammenfassung:CERTAIN strains of the insect pathogen Bacillus thuringiensis produce a heat-stable exotoxin which is toxic to species from several orders of insects 1,2 and also affects mammals 3–5 . The exotoxin inhibits ecdysone-stimulated insect RNA polymeras of mice both in vivo 6 and in vitro 7 .
ISSN:0028-0836
1476-4687
DOI:10.1038/253058a0