STABILITY STUDIES WITH AMPHOTERICIN B AND AMPHOTERICIN B METHYL ESTER

STABILITY STUDIES WITH AMPHOTERICIN B AND AMPHOTERICIN B METHYL ESTER

In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methyl ester salts. However, when pH is adjust...

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Veröffentlicht in:Journal of antibiotics 1975, Vol.28(2), pp.132-135
Hauptverfasser: BONNER, D. P., MECHLINSKI, W., SCHAFFNER, C. P.
Format: Artikel
Sprache:eng
Schlagworte:
Amphotericin B - pharmacology
Drug Stability
Esters
Hydrogen-Ion Concentration
Saccharomyces cerevisiae - drug effects
Solubility
Temperature
Time Factors
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Zusammenfassung:In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methyl ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5°C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.28.132