Studies in Type I glycogenosis: The paradoxical effect of ethanol on lactate

Paradoxically, ethanol, which raises lactate in normal individuals, lowers the elevated levels of lactate in patients with Type I glycogenosis. We found that, although lactate levels fell, pyruvate proportionately declined even more, resulting in an increased L/P ratio which indicates that, as in th...

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Veröffentlicht in:The Journal of pediatrics 1975, Vol.86 (1), p.37-42
Hauptverfasser: Sadeghi-Nejad, Abdollah, Hochman, Hillel, Senior, Boris
Format: Artikel
Sprache:eng
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Zusammenfassung:Paradoxically, ethanol, which raises lactate in normal individuals, lowers the elevated levels of lactate in patients with Type I glycogenosis. We found that, although lactate levels fell, pyruvate proportionately declined even more, resulting in an increased L/P ratio which indicates that, as in the normal, the oxidation of ethanol had generated NADH. In type I glycogenosis, the increased level of pyruvate-lactate derives from glycogenolysis. We found that, despite continued glycogenolysis, ethanol had caused less pyruvate-lactate to form. The effect of an increased NADH/NAD + ratio on the flow of carbon through the Embden-Meyerhof pathway could account for the finding, presumably by its effect on the oxidation-reduction couples with diversion of carbon toward formation of triglyceride rather than pyruvate-lactate.
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(75)80701-3