Benzmalecene: Inhibition of Cholesterol Biosynthesis and Hypocholesteremic Effect in Rats

Benzmalecene: Inhibition of Cholesterol Biosynthesis and Hypocholesteremic Effect in Rats

Summary Benzmalecene inhibited in vitro incorporation of 2-C14-mevalonic acid into cholesterol by rat liver homogenates. The inhibition proved to be non-competitive. Oral administration of this compound to normal rats resulted in a significant reduction in plasma cholesterol.

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1960-01, Vol.103 (1), p.41-43
Hauptverfasser: Huff, Jesse W., Gilfillan, James L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anticholesteremic Agents
Lipid Metabolism Disorders
Lipogenesis
Maleates - pharmacology
Old Medline
Rats
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Zusammenfassung:Summary Benzmalecene inhibited in vitro incorporation of 2-C14-mevalonic acid into cholesterol by rat liver homogenates. The inhibition proved to be non-competitive. Oral administration of this compound to normal rats resulted in a significant reduction in plasma cholesterol.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-103-25405