Anti‐cytoplasmic factors in the sera of patients with systemic lupus erythematosus and certain other diseases

Complement fixation reactions were obtained with the use of cytoplasmic cellular constituents and sera from patients with S.L.E. as well as sera from cases of primary biliary cirrhosis and Sjogren's syndrome. These reactions were independent of those involving nuclear components. The serum proteins responsible for the described reactions were shown to be gamma globulins. Evidence was produced that different constituents of microsomes were responsible for the reactions in the different diseases. Reactiones de fixation de complemento esseva obtenite in experimentos con constituentes cytoplasmic e seros ab patientes con systemic lupus erythematose e etiam seros ab casos de primaria cirrhosis biliari e le syndrome de Sjogren. Iste reactiones esseva independente del reactiones in que componentes nucleari participa. Esseva monstrate que le proteinas seral responsabile pro le describite reactiones esseva globulinas gamma. Certe observationes pareva indicar que differente constituentes de microsomas esseva responsabile pro le reactiones in le differente morbos.