Effect of Pituitary Growth Hormone in vivo on the Phosphorus/Oxygen Ratios of Isolated Rat Liver Mitochondria

Effect of Pituitary Growth Hormone in vivo on the Phosphorus/Oxygen Ratios of Isolated Rat Liver Mitochondria

RECENT reports tending to localize the site of action of thyroxine in uncoupling oxidative phosphorylation at the level of the mitochondrial membrane 1,2 have served to emphasize the need for similar studies on possible sites of action of anterior pituitary growth hormone, a substance which produces...

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Veröffentlicht in:Nature (London) 1960-04, Vol.186 (4722), p.392-393
Hauptverfasser: GRAYMORE, C. N, MELHUISH, A. H, GREENBAUM, A. L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biochemical Phenomena
Growth Hormone - pharmacology
Humanities and Social Sciences
letter
Liver - pharmacology
Mitochondria
Mitochondria, Liver
multidisciplinary
Old Medline
Oxygen - metabolism
Phosphorus - metabolism
Rats
Science
Science (multidisciplinary)
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Beschreibung
Zusammenfassung:RECENT reports tending to localize the site of action of thyroxine in uncoupling oxidative phosphorylation at the level of the mitochondrial membrane 1,2 have served to emphasize the need for similar studies on possible sites of action of anterior pituitary growth hormone, a substance which produces generalized metabolic changes even more striking than those found with thyroxine. The present communication reports some results concerning the effect of the hormone on oxidative phosphorylation, using mitochondria isolated from the livers of normal rats or rats treated with growth hormone.
ISSN:0028-0836
1476-4687
DOI:10.1038/186392b0