Antiparasitic nitroimidazoles. 8. Derivatives of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole

A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard rea...

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Veröffentlicht in:	Journal of medicinal chemistry 1975-02, Vol.18 (2), p.158-161
Hauptverfasser:	Ross, William J, Jamieson, William B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals - chemical synthesis Acetals - therapeutic use Animals Chagas Disease - drug therapy Dose-Response Relationship, Drug Hydrazones - chemical synthesis Hydrazones - therapeutic use Mice Nitroimidazoles - chemical synthesis Nitroimidazoles - therapeutic use Structure-Activity Relationship Styrenes - chemical synthesis Styrenes - therapeutic use Trypanocidal Agents - chemical synthesis Trypanocidal Agents - therapeutic use Trypanosoma brucei gambiense Trypanosoma cruzi Trypanosomiasis, African - drug therapy
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Beschreibung
Zusammenfassung:	A series of 33 thioacetals and hydrazones of 2-(4-formylstyryl)-5-nitro-1-vinylimidazole was prepared and examined for antitrypanosomal properties. The thioacetals were inactive as antitrypanosomal agents but three hydrazones derived from N-aminoguanidine, pyridylacethohydrazide chloride (Girard reagent P), and dimethylaminoacetohydrazide (Girard reagent D) displayed good activity against Trypanosoma rhodesiense.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00236a009