The effect of hyperventilation on rheumatoid arthritis

Clinical improvement in rheumatoid arthritis has been observed in certain situations associated with hyperventilation. A consistent pharmacological effect of massive aspirin therapy is hyperventilation. In this preliminary study, the authors tested the hypothesis that the symptomatic improvement with aspirin therapy in rheumatoid arthritis is related to the ventilatory effects of the drug. Hyperventilation induced by using a Drinker respirator simulated some of the clinical effects of massive aspirin therapy. Improvement was correlated better with alveolar pCO2 levels than with aspirin dosage or serum salicylate levels. Significant but unexplained improvement in sedimentation rates occurred after respirator hyperventilation. Melioration clinic de arthritis rheumatoide ha essite observate in certe situationes associate con hyperventilation. Un infallibile effecto pharmacologic del massive therapia a aspirina es hyperventilation. In le hic–reportate studio, que es de character preliminari, le autores ha testate le hypothese que le melioration symptomatic effectuate per aspirina in arthritis rheumatoide es relationate al effectos ventilatori de droga. Hyperventilation inducite per le uso de un respirator de Drinker simulava certes del effectos clinic de un massive therapia a aspirina. Le grados de melioration esseva melio correlationate con le nivellos alveolar de pCO2 que con le dosage de aspirina o le nivelos seral de salicylato. Grados significative sed non explicate de melioration del sedimentation erythrocytic occurreva post hyperventilation effectuate per medio del respirator.