Tryptoline Formation by a Preparation from Brain with 5-Methyltetrahydrofolic Acid and Tryptamine

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vit...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1975-03, Vol.187 (4179), p.853-855
Hauptverfasser:	Wyatt, Richard J., Erdelyi, Elizabeth, DoAmaral, Jefferson R., Elliott, Glen R., Renson, Jean, Barchas, Jack D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Brain - enzymology Chromatography Enzymes Gibbon ape leukemia virus Humans Hydrogen-Ion Concentration Indoles Indoles - metabolism Ions Kinetics Leukemia Methylation Piperidines - metabolism Solvents Structure-Activity Relationship Tetrahydrofolates - metabolism Tissue Extracts Tryptamines - metabolism Viruses
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Beschreibung
Zusammenfassung:	An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido[3,4-b]indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.234627