Migration inhibitory factor (MIF) production by skin fibroblast cultures from patients with severe combined immunodeficiency

The supernatants of fibroblast cultures derived from skin biopsies of each of two patients with severe combined immunodeficiency were studied for the presence of migration inhibitory activity (MIF). The supernatants of both of these fibroblast cultures were found to contain inhibitory activity for t...

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Veröffentlicht in:	Cellular immunology 1974-05, Vol.12 (2), p.326-330
Hauptverfasser:	Papageorgiou, Photini S., Glade, Philip R.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - immunology Cell Migration Inhibition Cells, Cultured Fibroblasts - immunology Histiocytosis, Langerhans-Cell - immunology Humans Immunologic Deficiency Syndromes - immunology Lectins Lymphocyte Activation Lymphocyte Depletion Macrophage Migration-Inhibitory Factors - biosynthesis Muramidase Serum Albumin, Bovine Serum Albumin, Radio-Iodinated Skin - cytology Skin - immunology Skin Tests T-Lymphocytes - immunology
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Zusammenfassung:	The supernatants of fibroblast cultures derived from skin biopsies of each of two patients with severe combined immunodeficiency were studied for the presence of migration inhibitory activity (MIF). The supernatants of both of these fibroblast cultures were found to contain inhibitory activity for the migration of cultured human lymphoid cells (PGLC-33H). This MIF activity was found to share chromatographic similarities with the MIF contained in the supernatants of a lymphoid cell line (PGLC-33H) and phytohemagglutinin (PHA) and tuberculin (PPD) stimulated human peripheral lymphocytes. These data suggest that MIF is not solely a lymphoid product and that severe combined immunodeficiency does not represent a gene deletion for MIF production.
ISSN:	0008-8749 1090-2163
DOI:	10.1016/0008-8749(74)90086-0