The effect of a new carbonic anhydrase inhibitor (dichlorphenamide) in respiratory insufficiency

The effect of a new carbonic anhydrase inhibitor (dichlorphenamide) in respiratory insufficiency

The effect of a new carbonic anhydrase inhibitor, dichlorphenamide, has been studied in fifteen patients with respiratory insufficiency. All but one showed clinical improvement. In most cases marked improvement in arterial blood gas tension was associated with an increased alveolar ventilation. This...

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Veröffentlicht in:The American journal of medicine 1960-03, Vol.28 (3), p.368-375
Hauptverfasser: Naimark, Arnold, Brodovsky, David M., Cherniack, Reuben M.
Format: Artikel
Sprache:eng
Schlagworte:
Carbonic Anhydrase Inhibitors
Dichlorphenamide
Diuretics - therapy
Humans
Old Medline
Respiration
Respiratory Insufficiency
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Zusammenfassung:The effect of a new carbonic anhydrase inhibitor, dichlorphenamide, has been studied in fifteen patients with respiratory insufficiency. All but one showed clinical improvement. In most cases marked improvement in arterial blood gas tension was associated with an increased alveolar ventilation. This improvement has been sustained during prolonged administration of the drug. Possible mechanisms of action of this drug have been investigated and discussed.
ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(60)90168-6