Experience with Amphotericin in the Therapy of Histoplasmosis
We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real ne...
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| Veröffentlicht in: | Chest 1960-02, Vol.37 (2), p.144-156 |
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| container_issue | 2 |
| container_start_page | 144 |
| container_title | Chest |
| container_volume | 37 |
| creator | YATES, J.L. ATAY, M.N. LANGELUTTIG, H.V. BRASHER, C.A. FURCOLOW, M.L. |
| description | We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B. |
| doi_str_mv | 10.1378/chest.37.2.144 |
| format | Article |
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Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B.</description><identifier>ISSN: 0096-0217</identifier><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 2589-3890</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.37.2.144</identifier><identifier>PMID: 13846486</identifier><language>eng</language><publisher>United States: American College of Chest Physicians</publisher><subject>Amphotericin B ; Antifungal Agents - therapy ; Fungicides, Industrial ; Histoplasmosis - therapy ; Lung Diseases - therapy ; Old Medline</subject><ispartof>Chest, 1960-02, Vol.37 (2), p.144-156</ispartof><rights>1960 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-1f1cf9855d93a68f90f8719999128aff52c1951d2e6c71f60d79a0215e30b3b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13846486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YATES, J.L.</creatorcontrib><creatorcontrib>ATAY, M.N.</creatorcontrib><creatorcontrib>LANGELUTTIG, H.V.</creatorcontrib><creatorcontrib>BRASHER, C.A.</creatorcontrib><creatorcontrib>FURCOLOW, M.L.</creatorcontrib><title>Experience with Amphotericin in the Therapy of Histoplasmosis</title><title>Chest</title><addtitle>Dis Chest</addtitle><description>We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B.</description><subject>Amphotericin B</subject><subject>Antifungal Agents - therapy</subject><subject>Fungicides, Industrial</subject><subject>Histoplasmosis - therapy</subject><subject>Lung Diseases - therapy</subject><subject>Old Medline</subject><issn>0096-0217</issn><issn>0012-3692</issn><issn>2589-3890</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1960</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFPwyAYhonRuDm9ejQ9eWuF0hY4eFiW6UyWeJlnwihYlrZUaNX9e3FdMi8SEhLyvk--7wHgFsEEYUIfZKV8n2CSpAnKsjMwTXPKYkwZPAdTCFkRwxSRCbjyfgdhnhckuwQThGlWZLSYgsfld6ecUa1U0Zfpq2jedJXtw5c0bRRuX6loUyknun1kdbQyvrddLXxjvfHX4EKL2qub4zsDb0_LzWIVr1-fXxbzdSwxRX2MNJKa0TwvGRYF1QxqShALB6VUaJ2nErEclakqJEG6gCVhIsydKwy3eEvwDNyP3M7ZjyFszBvjpapr0So7eE7TghBMYQgmY1A6671TmnfONMLtOYL8Vxg_COOY8JQHYaFwdyQP20aVp_jR0IlYmffqyzjFfSPqOsTxyNrZwbWi_kOkY0EFIZ9GOe7lwW8ZyrLnpTX_DfMDg4CLHQ</recordid><startdate>196002</startdate><enddate>196002</enddate><creator>YATES, J.L.</creator><creator>ATAY, M.N.</creator><creator>LANGELUTTIG, H.V.</creator><creator>BRASHER, C.A.</creator><creator>FURCOLOW, M.L.</creator><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196002</creationdate><title>Experience with Amphotericin in the Therapy of Histoplasmosis</title><author>YATES, J.L. ; ATAY, M.N. ; LANGELUTTIG, H.V. ; BRASHER, C.A. ; FURCOLOW, M.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-1f1cf9855d93a68f90f8719999128aff52c1951d2e6c71f60d79a0215e30b3b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1960</creationdate><topic>Amphotericin B</topic><topic>Antifungal Agents - therapy</topic><topic>Fungicides, Industrial</topic><topic>Histoplasmosis - therapy</topic><topic>Lung Diseases - therapy</topic><topic>Old Medline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YATES, J.L.</creatorcontrib><creatorcontrib>ATAY, M.N.</creatorcontrib><creatorcontrib>LANGELUTTIG, H.V.</creatorcontrib><creatorcontrib>BRASHER, C.A.</creatorcontrib><creatorcontrib>FURCOLOW, M.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YATES, J.L.</au><au>ATAY, M.N.</au><au>LANGELUTTIG, H.V.</au><au>BRASHER, C.A.</au><au>FURCOLOW, M.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experience with Amphotericin in the Therapy of Histoplasmosis</atitle><jtitle>Chest</jtitle><addtitle>Dis Chest</addtitle><date>1960-02</date><risdate>1960</risdate><volume>37</volume><issue>2</issue><spage>144</spage><epage>156</epage><pages>144-156</pages><issn>0096-0217</issn><issn>0012-3692</issn><eissn>2589-3890</eissn><eissn>1931-3543</eissn><abstract>We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B.</abstract><cop>United States</cop><pub>American College of Chest Physicians</pub><pmid>13846486</pmid><doi>10.1378/chest.37.2.144</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0096-0217 |
| ispartof | Chest, 1960-02, Vol.37 (2), p.144-156 |
| issn | 0096-0217 0012-3692 2589-3890 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82677380 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amphotericin B Antifungal Agents - therapy Fungicides, Industrial Histoplasmosis - therapy Lung Diseases - therapy Old Medline |
| title | Experience with Amphotericin in the Therapy of Histoplasmosis |
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