Experience with Amphotericin in the Therapy of Histoplasmosis

We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real ne...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chest 1960-02, Vol.37 (2), p.144-156
Hauptverfasser: YATES, J.L., ATAY, M.N., LANGELUTTIG, H.V., BRASHER, C.A., FURCOLOW, M.L.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We have reported our experience with the use of Amphotericin B therapy in 29 cases of proved active histoplasmosis, and one strongly suspected case. Our results apparently show that the drug is effective, but is primarily suppressive. Although it is the best therapy available now, there is a real need for further study and development of other antifungal agents which can be used in conjunction with Amphotericin and perhaps other methods of administration of the drug should be studied. Also, in view of the toxic effects, the manufacturers should be encouraged to attempt to purify and obtain the active principle in Amphotericin B.
ISSN:0096-0217
0012-3692
2589-3890
1931-3543
DOI:10.1378/chest.37.2.144