Accumulation of Dermal Mucopolysaccharides in Animals Following Injection of Estradiol Benzoate.

Summary Accumulation of mucopolysaccharides in response to estradiol benzoate inoculation in the skin of various rodents was studied. Only white Swiss mice responded with increased accumulation. Rats, guinea pigs, and hamsters did not show this response. Neither age, sex of the animal, nor dose of estradiol had any effect on amount of mucopolysaccharide accumulated. This activity of estradiol was neither effected by castration of males nor reversed by administration of cortisone.