The effect of prednisolone on the rat phrenic nerve-diaphragm preparation treated with hemicholinium

Recent papers have reported the benificial action of corticosteroids in myasthenia gravis. The underlying mechanism of action is not known. In a preliminary investigation the effect of prednisolone on the rat phrenic nerve-diaphragm preparation was studied. It was shown that a relatively high stimul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1974-11, Vol.29 (1), p.165-167
Hauptverfasser:	Wolters, Erik Ch.M.J., Leeuwin, Remy S., Van Wijngaarden, George K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corticosteroids Diaphragm - drug effects Dose-Response Relationship, Drug Electric Stimulation Female Hemicholinium 3 - antagonists & inhibitors Hemicholinium 3 - pharmacology Hemicholinium-3 In Vitro Techniques Muscle Contraction - drug effects Myasthenia gravis Phrenic Nerve - drug effects Phrenic nerve-diaphragm preparation Prednisolone - pharmacology Rats Rats, Inbred Strains Synaptic Transmission - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent papers have reported the benificial action of corticosteroids in myasthenia gravis. The underlying mechanism of action is not known. In a preliminary investigation the effect of prednisolone on the rat phrenic nerve-diaphragm preparation was studied. It was shown that a relatively high stimulation rate which caused ‘fatigue’ of the preparation, prednisolone prevented the blocking effect of hemicholinium-3, but had no effect on the preparation prior to addition of hemicholinium.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(74)90184-8