Collagen fractions in lathyritic rats

Collagen fractions in lathyritic rats

The effect of β-aminopropionitrile (“Lathyrism”) on collagen was studied. Albino rats were fed with a diet containing 73 per cent sweet peas, and the bone changes resulting were ascertained by x-ray studies. The collagen fractions were prepared from skin and bone by extraction with disodium phosphat...

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Veröffentlicht in:Biochemical pharmacology 1960-06, Vol.3 (3), p.181-183
Hauptverfasser: Mikkonen, L., Tuominen, T., Kulonen, E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Collagen - chemistry
Cyanides - pharmacology
Lathyrism
Old Medline
Rats
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Zusammenfassung:The effect of β-aminopropionitrile (“Lathyrism”) on collagen was studied. Albino rats were fed with a diet containing 73 per cent sweet peas, and the bone changes resulting were ascertained by x-ray studies. The collagen fractions were prepared from skin and bone by extraction with disodium phosphate solution, acid citrate solution, and by gelatinization. The alkali-soluble collagen was 5 times greater in cases of lathyrism. The solubility of non-collagenous proteins was also increased. The total collagen content was not altered.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(60)90105-2