C3 activation and T-independent B cell stimulation

SOME highly polymerised immunogens with repeated antigenic determinants, such as bacterial polysaccharides or polymerised flagellin and hapten conjugates of these, can stimulate mouse B lymphocytes to make antibody without requiring the cooperative helper activity of T lymphocytes 1 . The mechanism...

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Veröffentlicht in:	Nature (London) 1974-12, Vol.252 (5483), p.505-507
Hauptverfasser:	PRYJMA, JULIUSZ, HUMPHREY, JOHN H, KLAUS, GERRY G. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Animals Antibody Formation - drug effects Antibody Specificity Antigen-Antibody Reactions B-Lymphocytes - immunology Complement System Proteins Dinitrophenols - immunology Enterobacter - immunology Escherichia coli - immunology Ethylene Glycols - pharmacology Humanities and Social Sciences Hyaluronic Acid - immunology Immunoelectrophoresis In Vitro Techniques letter Magnesium - pharmacology Mice Mice, Inbred C3H multidisciplinary Polysaccharides, Bacterial - immunology Salmonella - immunology Science Science (multidisciplinary) Serratia marcescens - immunology Serum Albumin, Bovine Sheep - immunology Shigella - immunology T-Lymphocytes - immunology
Online-Zugang:	Volltext
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