C3 activation and T-independent B cell stimulation
SOME highly polymerised immunogens with repeated antigenic determinants, such as bacterial polysaccharides or polymerised flagellin and hapten conjugates of these, can stimulate mouse B lymphocytes to make antibody without requiring the cooperative helper activity of T lymphocytes 1 . The mechanism...
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Veröffentlicht in: | Nature (London) 1974-12, Vol.252 (5483), p.505-507 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | SOME highly polymerised immunogens with repeated antigenic determinants, such as bacterial polysaccharides or polymerised flagellin and hapten conjugates of these, can stimulate mouse B lymphocytes to make antibody without requiring the cooperative helper activity of T lymphocytes
1
. The mechanism whereby such T-independent immunogens, after interaction with the surface receptors on specifically responsive B lymphocytes, trigger these into activity is uncertain. Dukor and Hartmann
2
have postulated that binding of activated C3 to complement receptors on B cells acts as a necessary second signal for antibody production. They envisage that T-independent antigens and B-cell mitogens generate this second signal by their ability to activate C3 through the ‘bypass’ pathway, whereas in the case of T-dependent antigens the signal derives from C3 cleavage by proteases released by activated T cells. |
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ISSN: | 0028-0836 1476-4687 |
DOI: | 10.1038/252505a0 |