The Antibody Response to Myelin Basic Protein in Lewis and Fischer Rats as Followed by a Sodium Sulfate Method of Radioimmunoassay

It was found that the sodium sulfate method of radioimmunoassay of 125I-labeled myelin basic protein could be used in the measurement and linear regression analysis of myelin-basic protein-binding activity in Lewis and Fischer rats, and could be adapted to the day-to-day single point measurements of...

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Veröffentlicht in:	The Journal of immunology (1950) 1974-12, Vol.113 (6), p.1952-1957
Hauptverfasser:	Day, Eugene D, Wexler, Marjorie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Encephalomyelitis, Autoimmune, Experimental - immunology Freund's Adjuvant Immune Sera Immunization Immunization, Secondary Iodine Radioisotopes Isotope Labeling Male Myelin Basic Protein Myelin Sheath - immunology Radioimmunoassay Rats Rats, Inbred F344 Rats, Inbred Lew Sodium Tetradecyl Sulfate
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Beschreibung
Zusammenfassung:	It was found that the sodium sulfate method of radioimmunoassay of 125I-labeled myelin basic protein could be used in the measurement and linear regression analysis of myelin-basic protein-binding activity in Lewis and Fischer rats, and could be adapted to the day-to-day single point measurements of antibody in microliter quantities of serum without untoward loss of statistical precision.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.113.6.1952