Epithelial Changes in Vaginal Isografts in Male Mice.

Summary 1. Isografts of intact immature vaginas grew maximally in castrated male mice with ovarian transplants and minimally in intact males with similar grafts. Growth was intermediate in castrated or intact males without ovarian grafts. 2. Vaginal grafts showed one or 2 estrous phases in castrated males with ovarian grafts between 4 and 5 months after grafting but otherwise remained in late proestrus. Such activity did not occur in castrated males without ovarian transplants or in intact males with or without ovarian transplants, vaginal grafts in these hosts remaining in diestrus.