Decomposition of BCNU (1,3-Bis(2-chloroethyl)-1-nitrosourea) in aqueous solution

Decomposition of BCNU (1,3-Bis(2-chloroethyl)-1-nitrosourea) in aqueous solution

BCNU, labelled with 14C in the chloroethyl groups, decomposes in neutral aqueous solution to release half of its radioactivity as volatile products. These have been identified by a combination of gas chromatography and mass spectrometry as vinyl chloride, acetaldehyde, dichloroethane, and chloroetha...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 1974-09, Vol.60 (2), p.515-520
Hauptverfasser: Colvin, Michael, Wayne Cowens, J., Brundrett, Robert B., Kramer, Barnett S., Ludlum, David B.
Format: Artikel
Sprache:eng
Schlagworte:
Acetaldehyde
Carbon Radioisotopes
Carmustine
Chromatography, Gas
Colorimetry
Drug Stability
Ethylamines
Kinetics
Mass Spectrometry
Solubility
Time Factors
Vinyl Compounds - analysis
Water
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BCNU, labelled with 14C in the chloroethyl groups, decomposes in neutral aqueous solution to release half of its radioactivity as volatile products. These have been identified by a combination of gas chromatography and mass spectrometry as vinyl chloride, acetaldehyde, dichloroethane, and chloroethanol. This set of products is consistent with the existence of chloroethylcarbonium ions as reactive intermediates which would produce the previously described substituted nucleotides.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(74)90270-8