Malignant lymphoma (so‐called reticulum cell sarcoma) of bone

The probability of 5‐year survival for 98 patients with “primary” skeletal lymphoma was 44%. For 81 additional patients with a similar skeletal lesion producing their initial clinical problem but found to have multifocal disease, the probability of 5‐year survival was 23%. Skeletal roentgenologic survey, sternal marrow aspiration, and probably lymphangiography should be employed in assessing such patients. Pulmonary involvement was extremely unusual. Radiation is the treatment of choice. Surgical ablation may be necessary for persistent or recurrent disease. Chemotherapy may be of value for patients with disseminated involvement.