Echinomycin: a bifunctional intercalating antibiotic

Echinomycin: a bifunctional intercalating antibiotic

The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a bifunctional mode of intercalation. Binding parameters for a variety of natural and synthetic DNAs vary widely, indicating that echinomycin interacts selectively with specif...

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Veröffentlicht in:Nature (London) 1974-12, Vol.252 (5485), p.653-657
Hauptverfasser: Waring, M. J, Wakelin, L. P. G
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - metabolism
Binding Sites
Cytosine Nucleotides - metabolism
DNA - metabolism
DNA, Circular - metabolism
Ethidium - metabolism
Guanine Nucleotides - metabolism
Humanities and Social Sciences
Kinetics
Magnetic Resonance Spectroscopy
Mass Spectrometry
multidisciplinary
Nucleic Acid Conformation
Peptides, Cyclic - metabolism
Poly A-U - metabolism
Polynucleotides - metabolism
Protein Binding
Protein Conformation
Quinoxalines - metabolism
Science
Science (multidisciplinary)
Structure-Activity Relationship
Thymine Nucleotides - metabolism
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Beschreibung
Zusammenfassung:The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a bifunctional mode of intercalation. Binding parameters for a variety of natural and synthetic DNAs vary widely, indicating that echinomycin interacts selectively with specific nucleotide sequences.
ISSN:0028-0836
1476-4687
DOI:10.1038/252653a0