Cholera enterotoxin stimulation of cAMP in cultured adrenal tumor cells

Cholera enterotoxin stimulation of cAMP in cultured adrenal tumor cells

Cholera enterotoxin (CT) increased the concentration of adenosine 3′-5′-cyclic monophosphate (cAMP) in monolayer cultures of adrenal tumor cells after a 60 min lag phase in contrast to the rapid effect of adrenocorticotropin (ACTH). The change in intracellular cAMP was accompanied by the release of...

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Veröffentlicht in:Experimental cell research 1974-08, Vol.87 (2), p.436-438
Hauptverfasser: Kwan, Catherine N., Wishnow, R.M.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Gland Neoplasms - metabolism
Adrenal Glands - drug effects
Adrenocorticotropic Hormone - metabolism
Adrenocorticotropic Hormone - pharmacology
Animals
Cells, Cultured
Cyclic AMP - metabolism
Enterotoxins - pharmacology
Mice
Stimulation, Chemical
Time Factors
Vibrio cholerae
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Zusammenfassung:Cholera enterotoxin (CT) increased the concentration of adenosine 3′-5′-cyclic monophosphate (cAMP) in monolayer cultures of adrenal tumor cells after a 60 min lag phase in contrast to the rapid effect of adrenocorticotropin (ACTH). The change in intracellular cAMP was accompanied by the release of steroids into the culture medium and a reversible alteration of monolayer morphology.
ISSN:0014-4827
1090-2422
DOI:10.1016/0014-4827(74)90513-8