TRF CONCENTRATIONS IN VARIOUS TISSUES FOLLOWING ANTERIOR HYPOTHALAMIC LESIONS

1. When electrolytic lesions were produced in bilateral anterior-hypothalamus in the dog, TRF almost disappeared from the body and could not be detected in the neurohypophysis, cerebrospinal fluid and blood as well as in the anterior hypothalamus. Nor was it excreted in urine. 2. These results are in accordance with the previous report that TRF was present only in the extract of the anterior hypothalamus, but not in the other parts of the central nervous system. It was therefore concluded that the site of Production of TRF is the anterior hypothalamus.