Effect of Certain Tranquilizers on The Reticulo Endothelial System

Effect of Certain Tranquilizers on The Reticulo Endothelial System

Summary Administration of excessive doses of certain tranquilizers decreased the phagocytic activity of the reticulo endothelial system. This decrease of phagocytic activity did not occur in adrenalectomized animals given hydroxyzine. The significance of this finding is discussed in relation to the...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1959-10, Vol.102 (1), p.88-90
Hauptverfasser: Vinegar, R., Berger, F. M.
Format: Artikel
Sprache:eng
Schlagworte:
Mononuclear Phagocyte System - pharmacology
Old Medline
Tranquilizing Agents - pharmacology
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Zusammenfassung:Summary Administration of excessive doses of certain tranquilizers decreased the phagocytic activity of the reticulo endothelial system. This decrease of phagocytic activity did not occur in adrenalectomized animals given hydroxyzine. The significance of this finding is discussed in relation to the strong RES inhibition produced by corticosteroids (6.2).
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-102-25152