Evidence for a unique kind of α-type globin chain in early mammalian embryos

Evidence for a unique kind of α-type globin chain in early mammalian embryos

MAMMALIAN embryonic haemoglobins are synthesised in nucleated erythroid cells derived from the yolk sac 1 . They are structurally different from foetal and adult haemoglobins. It has been generally assumed that the difference of embryonic to foetal or adult haemoglobin is solely due to an embryonic...

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Veröffentlicht in:Nature (London) 1974-08, Vol.250 (5469), p.774-776
Hauptverfasser: MELDERIS, H, STEINHEIDER, G, OSTERTAG, W
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - analysis
Animals
Embryo, Mammalian - analysis
Embryo, Mammalian - metabolism
Gestational Age
Hemoglobins - analysis
Hemoglobins - biosynthesis
Humanities and Social Sciences
Humans
letter
Leucine - metabolism
Mice
multidisciplinary
Rabbits
Science
Science (multidisciplinary)
Tritium
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Zusammenfassung:MAMMALIAN embryonic haemoglobins are synthesised in nucleated erythroid cells derived from the yolk sac 1 . They are structurally different from foetal and adult haemoglobins. It has been generally assumed that the difference of embryonic to foetal or adult haemoglobin is solely due to an embryonic globin chain structurally related to the β chain. It was believed that embryos either synthesise no α-type chain at all or an α chain structurally identical to the adult α chain 2,3 .
ISSN:0028-0836
1476-4687
DOI:10.1038/250774a0