Mass spectrometric studies of the interaction of platinum complexes with nucleoside analogues

Mass spectrometric studies of the interaction of platinum complexes with nucleoside analogues

Mass spectrometry has been used to investigate the interaction of a number of cis- and trans-Pt(amine) 2Cl 2 complexes with nucleoside analogues. 9-Methyladenine 1-methylcytosine react as monodentate ligands and replace a chloride in the platinum complex. 9-Methylguanine reacts as a bidentate ligand...

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Veröffentlicht in:Chemico-biological interactions 1974-06, Vol.8 (6), p.421-427
Hauptverfasser: Roos, I.A.G., Thomson, A.J., Eagles, J.
Format: Artikel
Sprache:eng
Schlagworte:
Adenine
Binding Sites
Cytosine
Guanine
Ligands
Mass Spectrometry
Methylation
Molecular Conformation
Nucleic Acid Conformation
Platinum
Structure-Activity Relationship
Thymine
Time Factors
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Zusammenfassung:Mass spectrometry has been used to investigate the interaction of a number of cis- and trans-Pt(amine) 2Cl 2 complexes with nucleoside analogues. 9-Methyladenine 1-methylcytosine react as monodentate ligands and replace a chloride in the platinum complex. 9-Methylguanine reacts as a bidentate ligand and 1-methylthymine does not appear to react at all. Analysis of the mass spectral data, in particular the isotope ratios, have been used to establish the composition of various reaction products, but little evidence has been derived to confirm the structure of the linkage.
ISSN:0009-2797
1872-7786
DOI:10.1016/0009-2797(74)90048-9