Routine measurements of liver and bone alkaline phosphatase in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer
A method suitable for routine determination of liver and bone alkaline phosphatase (EC 3.1.3.1) on the LKB 8600 is described. Experimental data on differential inhibition by l-phenylalanine, 10 mmoles/1 and carbamide, 3.81 moles/1 under strictly controlled conditions on the LKB 8600 are given. Data...
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| Veröffentlicht in: | Clinica chimica acta 1974-06, Vol.53 (3), p.281-290 |
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| container_title | Clinica chimica acta |
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| creator | Gerhardt, W. Nielsen, M.Lykkegaard Vagn Nielsen, O. Olsen, J.S. Statland, B.E. |
| description | A method suitable for routine determination of liver and bone alkaline phosphatase (EC 3.1.3.1) on the LKB 8600 is described. Experimental data on differential inhibition by
l-phenylalanine, 10 mmoles/1 and carbamide, 3.81 moles/1 under strictly controlled conditions on the LKB 8600 are given. Data on the stability of the tissue alkaline phosphatase extracts and on the precision of the analytical system are provided. The method permits the determination of 15 samples per h. |
| doi_str_mv | 10.1016/0009-8981(74)90266-6 |
| format | Article |
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l-phenylalanine, 10 mmoles/1 and carbamide, 3.81 moles/1 under strictly controlled conditions on the LKB 8600 are given. Data on the stability of the tissue alkaline phosphatase extracts and on the precision of the analytical system are provided. The method permits the determination of 15 samples per h.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(74)90266-6</identifier><identifier>PMID: 4847103</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alkaline Phosphatase - antagonists & inhibitors ; Alkaline Phosphatase - blood ; Alkaline Phosphatase - metabolism ; Autoanalysis ; Bone and Bones - enzymology ; Child, Preschool ; Drug Stability ; Evaluation Studies as Topic ; Humans ; Jejunum - enzymology ; Kinetics ; Liver - enzymology ; Mathematics ; Methods ; Phenylalanine - pharmacology ; Temperature ; Time Factors ; Urea - pharmacology</subject><ispartof>Clinica chimica acta, 1974-06, Vol.53 (3), p.281-290</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-8981(74)90266-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4847103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerhardt, W.</creatorcontrib><creatorcontrib>Nielsen, M.Lykkegaard</creatorcontrib><creatorcontrib>Vagn Nielsen, O.</creatorcontrib><creatorcontrib>Olsen, J.S.</creatorcontrib><creatorcontrib>Statland, B.E.</creatorcontrib><title>Routine measurements of liver and bone alkaline phosphatase in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>A method suitable for routine determination of liver and bone alkaline phosphatase (EC 3.1.3.1) on the LKB 8600 is described. Experimental data on differential inhibition by
l-phenylalanine, 10 mmoles/1 and carbamide, 3.81 moles/1 under strictly controlled conditions on the LKB 8600 are given. Data on the stability of the tissue alkaline phosphatase extracts and on the precision of the analytical system are provided. The method permits the determination of 15 samples per h.</description><subject>Alkaline Phosphatase - antagonists & inhibitors</subject><subject>Alkaline Phosphatase - blood</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Autoanalysis</subject><subject>Bone and Bones - enzymology</subject><subject>Child, Preschool</subject><subject>Drug Stability</subject><subject>Evaluation Studies as Topic</subject><subject>Humans</subject><subject>Jejunum - enzymology</subject><subject>Kinetics</subject><subject>Liver - enzymology</subject><subject>Mathematics</subject><subject>Methods</subject><subject>Phenylalanine - pharmacology</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Urea - pharmacology</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc2O1SAYhonRjMfRO9CElZlZ1IFCKXVhMn_qxJOYGF2Tr_RrilJaoZ3keFleoXTmxBWB9-Hh5yXkNWfvOOPqgjHWFLrR_KyW5w0rlSrUE7LjuhaFkE35lOz-I8_Ji5R-5qlkip-QE6llzZnYkb_fpnVxAemIkNaII4Yl0amn3t1jpBA62k45Bv8L_MbNw5TmARZISF2gwzpCoAnjOr6nN67vMWaDA5_DwbVucVOg7YH6Yh4wHDx4CJtmE1uILYyuQ3qWT4ZzmtFlQLr_ckW1YozmRfsgiLBsW8Af_mB8SZ714BO-Oo6n5MfH2-_Xn4v9109315f7AkvFl0JChVoC1ygVYMMrUWMHILTlglWiraQFrYVtW1napqv6LqOM1a1iom9qK07J20fvHKffK6bFjC5Z9PkFOK3J6FLqpmQ8g2-O4NqO2Jk5uhHiwRw_OecfHnPMt713GE2yDoPFzkW0i-kmZzgzW6lma8xsjZlamodSjRL_AIkblag</recordid><startdate>19740628</startdate><enddate>19740628</enddate><creator>Gerhardt, W.</creator><creator>Nielsen, M.Lykkegaard</creator><creator>Vagn Nielsen, O.</creator><creator>Olsen, J.S.</creator><creator>Statland, B.E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19740628</creationdate><title>Routine measurements of liver and bone alkaline phosphatase in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer</title><author>Gerhardt, W. ; Nielsen, M.Lykkegaard ; Vagn Nielsen, O. ; Olsen, J.S. ; Statland, B.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e261t-4a5e84a18e46ae91537edaa38c13053b54ca883cbb42c9d5fd18e007b603f97c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Alkaline Phosphatase - antagonists & inhibitors</topic><topic>Alkaline Phosphatase - blood</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Autoanalysis</topic><topic>Bone and Bones - enzymology</topic><topic>Child, Preschool</topic><topic>Drug Stability</topic><topic>Evaluation Studies as Topic</topic><topic>Humans</topic><topic>Jejunum - enzymology</topic><topic>Kinetics</topic><topic>Liver - enzymology</topic><topic>Mathematics</topic><topic>Methods</topic><topic>Phenylalanine - pharmacology</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Urea - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerhardt, W.</creatorcontrib><creatorcontrib>Nielsen, M.Lykkegaard</creatorcontrib><creatorcontrib>Vagn Nielsen, O.</creatorcontrib><creatorcontrib>Olsen, J.S.</creatorcontrib><creatorcontrib>Statland, B.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerhardt, W.</au><au>Nielsen, M.Lykkegaard</au><au>Vagn Nielsen, O.</au><au>Olsen, J.S.</au><au>Statland, B.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Routine measurements of liver and bone alkaline phosphatase in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1974-06-28</date><risdate>1974</risdate><volume>53</volume><issue>3</issue><spage>281</spage><epage>290</epage><pages>281-290</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>A method suitable for routine determination of liver and bone alkaline phosphatase (EC 3.1.3.1) on the LKB 8600 is described. Experimental data on differential inhibition by
l-phenylalanine, 10 mmoles/1 and carbamide, 3.81 moles/1 under strictly controlled conditions on the LKB 8600 are given. Data on the stability of the tissue alkaline phosphatase extracts and on the precision of the analytical system are provided. The method permits the determination of 15 samples per h.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4847103</pmid><doi>10.1016/0009-8981(74)90266-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1974-06, Vol.53 (3), p.281-290 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alkaline Phosphatase - antagonists & inhibitors Alkaline Phosphatase - blood Alkaline Phosphatase - metabolism Autoanalysis Bone and Bones - enzymology Child, Preschool Drug Stability Evaluation Studies as Topic Humans Jejunum - enzymology Kinetics Liver - enzymology Mathematics Methods Phenylalanine - pharmacology Temperature Time Factors Urea - pharmacology |
| title | Routine measurements of liver and bone alkaline phosphatase in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer |
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