EFFECTS OF BIOGENIC MONOAMINES AND PRECURSORS ON STRESS ULCERS AND SECRETION IN STOMACH

Effects of biogenic monoamines and their precursors on stress ulcers and secretion in stomach were investigated herein. Norepinephrine, 5-HT and their precursors prevented formation of stress ulcer at any level of endogenous monoamines in reserpine or iproniazid-treated rats. These same agents did n...

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Veröffentlicht in:Japanese journal of pharmacology 1974, Vol.24(2), pp.241-246
Hauptverfasser: NAKANE, Sadao, SAKAI, Takeshi
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container_title Japanese journal of pharmacology
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SAKAI, Takeshi
description Effects of biogenic monoamines and their precursors on stress ulcers and secretion in stomach were investigated herein. Norepinephrine, 5-HT and their precursors prevented formation of stress ulcer at any level of endogenous monoamines in reserpine or iproniazid-treated rats. These same agents did not affect the stressinduced decrease in the output of PSB but increased the pH value of gastric juice.
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subjects 5-Hydroxytryptophan - therapeutic use
Amines - pharmacology
Amines - therapeutic use
Animals
Dihydroxyphenylalanine - therapeutic use
Dopamine - therapeutic use
Gastric Juice - metabolism
Hydrogen-Ion Concentration
Iproniazid - pharmacology
Male
Norepinephrine - therapeutic use
Rats
Reserpine - pharmacology
Stomach - drug effects
Stomach Ulcer - drug therapy
title EFFECTS OF BIOGENIC MONOAMINES AND PRECURSORS ON STRESS ULCERS AND SECRETION IN STOMACH
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