EFFECTS OF BIOGENIC MONOAMINES AND PRECURSORS ON STRESS ULCERS AND SECRETION IN STOMACH

Effects of biogenic monoamines and their precursors on stress ulcers and secretion in stomach were investigated herein. Norepinephrine, 5-HT and their precursors prevented formation of stress ulcer at any level of endogenous monoamines in reserpine or iproniazid-treated rats. These same agents did n...

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Veröffentlicht in:	Japanese journal of pharmacology 1974, Vol.24(2), pp.241-246
Hauptverfasser:	NAKANE, Sadao, SAKAI, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - therapeutic use Amines - pharmacology Amines - therapeutic use Animals Dihydroxyphenylalanine - therapeutic use Dopamine - therapeutic use Gastric Juice - metabolism Hydrogen-Ion Concentration Iproniazid - pharmacology Male Norepinephrine - therapeutic use Rats Reserpine - pharmacology Stomach - drug effects Stomach Ulcer - drug therapy
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Zusammenfassung:	Effects of biogenic monoamines and their precursors on stress ulcers and secretion in stomach were investigated herein. Norepinephrine, 5-HT and their precursors prevented formation of stress ulcer at any level of endogenous monoamines in reserpine or iproniazid-treated rats. These same agents did not affect the stressinduced decrease in the output of PSB but increased the pH value of gastric juice.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.24.241