Determination of Isoniazid and Metabolites in Biological Fluids

Methods were developed for the determination of isoniazid and some of its metabolites in biological fluids. Isoniazid is determined in whole blood by a fluorometric procedure, and isoniazid and hydrazones, acetylisoniazid, isonicotinic acid, and isonicotinuric acid are determined in urine by colorim...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-08, Vol.63 (8), p.1191-1197
Hauptverfasser:	Boxenbaum, Harold G., Riegelman, Sidney
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adult Antituberculosis drugs-determination of isoniazid and metabolites in biological fluids Buffers Colorimetry Colorimetry-determination Colorimetry—determination, isoniazid and metabolites in biological fluids Fluorometry-determination Fluorometry—determination, isoniazid and metabolites in biological fluids Humans Hydrazones - analysis Hydrazones - urine Hydrolysis Isoniazid - analysis Isoniazid - blood Isoniazid - metabolism Isoniazid - urine isoniazid and metabolites in biological fluids Isoniazid and metabolites-fluorometric and colorimetric procedures for determination in biological samples Isonicotinic Acids - analysis Male Methods Middle Aged Spectrometry, Fluorescence Time Factors
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Beschreibung
Zusammenfassung:	Methods were developed for the determination of isoniazid and some of its metabolites in biological fluids. Isoniazid is determined in whole blood by a fluorometric procedure, and isoniazid and hydrazones, acetylisoniazid, isonicotinic acid, and isonicotinuric acid are determined in urine by colorimetry; each method is specific and accurate. Data are presented on these compounds following intravenous doses of isoniazid to both rapid and slow inactivator subjects of isoniazid.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600630804