Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.
Summary Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.
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| Veröffentlicht in: | Proceedings of the Society for Experimental Biology and Medicine 1960-10, Vol.105 (1), p.197-201 |
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| container_title | Proceedings of the Society for Experimental Biology and Medicine |
| container_volume | 105 |
| creator | Holtkamp, Dorsey E. Greslin, Joseph G. Root, Charles A. Lerner, Leonard J. |
| description | Summary
Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition. |
| doi_str_mv | 10.3181/00379727-105-26054 |
| format | Article |
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Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.</description><identifier>ISSN: 0037-9727</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-105-26054</identifier><identifier>PMID: 13715563</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Clomiphene ; Fertility ; Gonadotropins ; Gonadotropins, Pituitary - antagonists & inhibitors ; Humans ; Old Medline ; Pituitary Diseases ; Pituitary Gland ; Reproduction - pharmacology ; Stilbenes - pharmacology</subject><ispartof>Proceedings of the Society for Experimental Biology and Medicine, 1960-10, Vol.105 (1), p.197-201</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13715563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holtkamp, Dorsey E.</creatorcontrib><creatorcontrib>Greslin, Joseph G.</creatorcontrib><creatorcontrib>Root, Charles A.</creatorcontrib><creatorcontrib>Lerner, Leonard J.</creatorcontrib><title>Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.</title><title>Proceedings of the Society for Experimental Biology and Medicine</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.</description><subject>Clomiphene</subject><subject>Fertility</subject><subject>Gonadotropins</subject><subject>Gonadotropins, Pituitary - antagonists & inhibitors</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Pituitary Diseases</subject><subject>Pituitary Gland</subject><subject>Reproduction - pharmacology</subject><subject>Stilbenes - pharmacology</subject><issn>0037-9727</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1960</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10D1vwyAQBmBUtWrStH-gQ-WpGwkYMGaMoiSNFKlLOyNsICaywTX2kH9f52u60-nR6e4F4B2jOcE5XiBEuOAphxgxmGaI0QcwxYwwSDIhHsH0DOBZTMBLjEeEMONp9gwmmHDMWEamYL0NXunQd6GtnE92vnKF650_JMrrZOl7BzemHLx2_SlZW2vKPibBJquqDp1qXFsZb-av4MmqOpq3W52B3836Z_UF99_b3Wq5hy3moofaKit4XiqtU64QypkojKKZtlxbrEubW1tqWjKKVG6RFZSZQhtrSCHGPiUz8Hnd23bhbzCxl42Lpalr5U0YosxTyhGhdIQfNzgUjdGy7VyjupO8Pz6CxRVEdTDyGIbOj4dLjOQ5WnmPdhwweYmW_AND3WoG</recordid><startdate>196010</startdate><enddate>196010</enddate><creator>Holtkamp, Dorsey E.</creator><creator>Greslin, Joseph G.</creator><creator>Root, Charles A.</creator><creator>Lerner, Leonard J.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196010</creationdate><title>Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.</title><author>Holtkamp, Dorsey E. ; Greslin, Joseph G. ; Root, Charles A. ; Lerner, Leonard J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p179t-dfaf978cadd27a00859bea46df7df1dcf8ffcd4c540a8f0f945ebdefe3b994523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1960</creationdate><topic>Clomiphene</topic><topic>Fertility</topic><topic>Gonadotropins</topic><topic>Gonadotropins, Pituitary - antagonists & inhibitors</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Pituitary Diseases</topic><topic>Pituitary Gland</topic><topic>Reproduction - pharmacology</topic><topic>Stilbenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holtkamp, Dorsey E.</creatorcontrib><creatorcontrib>Greslin, Joseph G.</creatorcontrib><creatorcontrib>Root, Charles A.</creatorcontrib><creatorcontrib>Lerner, Leonard J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holtkamp, Dorsey E.</au><au>Greslin, Joseph G.</au><au>Root, Charles A.</au><au>Lerner, Leonard J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.</atitle><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1960-10</date><risdate>1960</risdate><volume>105</volume><issue>1</issue><spage>197</spage><epage>201</epage><pages>197-201</pages><issn>0037-9727</issn><eissn>1535-3699</eissn><abstract>Summary
Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13715563</pmid><doi>10.3181/00379727-105-26054</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Proceedings of the Society for Experimental Biology and Medicine, 1960-10, Vol.105 (1), p.197-201 |
| issn | 0037-9727 1535-3699 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Clomiphene Fertility Gonadotropins Gonadotropins, Pituitary - antagonists & inhibitors Humans Old Medline Pituitary Diseases Pituitary Gland Reproduction - pharmacology Stilbenes - pharmacology |
| title | Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene. |
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