Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.

Gonadotrophin Inhibiting and Anti-Fecundity Effects of Chloramiphene.

Summary Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.

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Veröffentlicht in:Proceedings of the Society for Experimental Biology and Medicine 1960-10, Vol.105 (1), p.197-201
Hauptverfasser: Holtkamp, Dorsey E., Greslin, Joseph G., Root, Charles A., Lerner, Leonard J.
Format: Artikel
Sprache:eng
Schlagworte:
Clomiphene
Fertility
Gonadotropins
Gonadotropins, Pituitary - antagonists & inhibitors
Humans
Old Medline
Pituitary Diseases
Pituitary Gland
Reproduction - pharmacology
Stilbenes - pharmacology
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Zusammenfassung:Summary Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.
ISSN:0037-9727
1535-3699
DOI:10.3181/00379727-105-26054