Electron Microscopic Study of Constitutional ICG Excretory Defect

Three cases with discrepancy of ICG and BSP test had been reported as “constitutional ICG excretory defect” These cases showed apparently low disappearance rate of ICG and relatively normal rate of BSP. Familial occurence was observed in one case of these three cases. In this paper the microscopic observations of the liver tissue which were obtained by needle biopsy were reported. By light micrographs there were no inflammatory changes and no increase of fiber in portal areas. There were some lipofuscin pigments and fat in hepatic cells, but these were within normal limits. Electron micrographs showed increased reticulum fiber in Disse's space. The mitochondria swelled, deformed and included paracrystalline. The smooth endoplasmic reticulum was appeared on the irregularly branching complex of small tubulus and vesicles. The unstratified rough endoplasmic reticulum showed fragmentations and dilatation of parallel arrays of ergastoplasm. The relations between constitutional hyperbilirubinemia and this disorder were discussed.