NEW ANTIBIOTICS, METHYLENOMYCINS A AND B: I. PRODUCING ORGANISM, FERMENTATION AND ISOLATION, BIOLOGICAL ACTIVITIES AND PHYSICAL AND CHEMICAL PROPERTIES

Methylenomycins A and B, two new antibiotics were found in the culture filtrate of a streptomycete strain No.2416, which was identified as a strain of Streptomyces violaceoruber. Their elementary analyses and mass spectroscopic measurements suggested that the molecular formula of methylenomycin A was C9H10O4 and that of methylenomycin B was C8H10O2. Methylenomycins A and B exhibited activities against gram-positive and gram-negative bacteria, and especially against Proteus.