Effects of Aromatic Aldehydes on O-Methylation of Dopamine and Norepinephrine in in Vitro

An increase in extracted radioactivity was found when the aromatic aldehydes 2-nitrobenzaldehyde or pyridine-4-carbox-aldehyde were incubated with catechol-O-methyltransferase in the presence of 14C-methyl-S-adenosylmethionine and dopamine or norepinephrine. The condensation products of dopamine wit...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1974-08, Vol.63 (8), p.1261-1264
Hauptverfasser:	Ho, Beng T., Gardner, Patricia M., Englert, Leo F., Walker, K.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aldehydes, aromatic—effects on catechol-O-methyltransferase and O-methylation of dopamine and norepinephrine in vitro, syntheses of Schiff bases and tetrahydroisoquinoline derivatives as substrates Animals aromatic-effects on catechol-O-methyltransferase and O-methylation of dopamine and norepinephrine in vitro Benzaldehydes Carbon Radioisotopes Catechol O-Methyltransferase Catechol-O-methyltransferase-effects of aromatic aldehydes Catechol-O-methyltransferase—effects of aromatic aldehydes, O-methylation of dopamine and norepinephrine in vitro Chemical Phenomena Chemistry Chromatography Dopamine Dopamine-effects of 2-nitrobenzaldehyde and pyridine-4-carboxaldehyde on O-methylation In Vitro Isoquinolines Kinetics Liver - enzymology Methylation Norepinephrine Norepinephrine-effects of 2-nitrobenzaldehyde and pyridine-4-carboxaldehyde on O-methylation In Vitro Normetanephrine O-methylation of dopamine and norepinephrine in vitro Pyridines Rats S-Adenosylmethionine Schiff Bases Spectrophotometry, Ultraviolet syntheses of Schiff bases and tetrahydroisoquinoline derivatives as substrates Tritium Tyramine - analysis
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Beschreibung
Zusammenfassung:	An increase in extracted radioactivity was found when the aromatic aldehydes 2-nitrobenzaldehyde or pyridine-4-carbox-aldehyde were incubated with catechol-O-methyltransferase in the presence of 14C-methyl-S-adenosylmethionine and dopamine or norepinephrine. The condensation products of dopamine with the two aldehydes were synthesized. The Schiff bases and tetrahydroisoquinoline derivatives were better substrates for catechol-O-methyltransferase than was dopamine or norepinephrine in terms of either Km or Vmax.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600630820