Influence of Coagulases and Route of Injection on Staphylococcal Virulence in Mice.

Influence of Coagulases and Route of Injection on Staphylococcal Virulence in Mice.

Summary Intraperitoneal and intravenous LD50 values of 12 strains of staphylococci, grouped according to free coagulase and the so-called clumping factor or bound coagulase, indicate that mouse virulence of S. aureus is influenced less by route of injection than by nature of the organisms injected....

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1960-12, Vol.105 (3), p.589-591
Hauptverfasser: Alami, Samih Y., Kelly, Floence C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Coagulase
Enzymes - pharmacology
Injections
Leadership
Mice
Old Medline
Staphylococcus - immunology
Virulence
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Beschreibung
Zusammenfassung:Summary Intraperitoneal and intravenous LD50 values of 12 strains of staphylococci, grouped according to free coagulase and the so-called clumping factor or bound coagulase, indicate that mouse virulence of S. aureus is influenced less by route of injection than by nature of the organisms injected. Mucin markedly enhanced mouse virulence for intraperitoneally injected coagulase positive, clumping factor negative staphylococci but not that of other strains. Neither free nor bound coagulase per se appeared to be a critical factor of virulence for mice.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-105-26186