Clinical evaluation of routine measurement of liver and bone alkaline phosphatases in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer
Determination of liver and bone alkaline phosphatase in human serum was carried out with a recently developed routine method using differential inhibition by l-phenylalanine and carbamide on the LKB 8600. Three groups of patients were investigated: 71 patients with hepato-biliary disorders, 22 patie...
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| Veröffentlicht in: | Clinica chimica acta 1974-06, Vol.53 (3), p.291-297 |
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| container_title | Clinica chimica acta |
| container_volume | 53 |
| creator | Gerhardt, W. Nielsen, M.Lykkegaard Nielsen, O.Vagn Olsen, J.S. Statland, B.E. |
| description | Determination of liver and bone alkaline phosphatase in human serum was carried out with a recently developed routine method using differential inhibition by
l-phenylalanine and carbamide on the LKB 8600.
Three groups of patients were investigated: 71 patients with hepato-biliary disorders, 22 patients with bone diseases, and 67 patients without recognizable hepato-biliary or bone diseases.
Agreement between the clinical diagnosis and the separate values of liver AP and bone AP was found in patients with elevated total alkaline phosphatase activities in serum. |
| doi_str_mv | 10.1016/0009-8981(74)90267-8 |
| format | Article |
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l-phenylalanine and carbamide on the LKB 8600.
Three groups of patients were investigated: 71 patients with hepato-biliary disorders, 22 patients with bone diseases, and 67 patients without recognizable hepato-biliary or bone diseases.
Agreement between the clinical diagnosis and the separate values of liver AP and bone AP was found in patients with elevated total alkaline phosphatase activities in serum.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/0009-8981(74)90267-8</identifier><identifier>PMID: 4847104</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alkaline Phosphatase - antagonists & inhibitors ; Alkaline Phosphatase - blood ; Alkaline Phosphatase - metabolism ; Autoanalysis ; Bone and Bones - enzymology ; Bone Diseases - diagnosis ; Bone Diseases - enzymology ; Colitis, Ulcerative - enzymology ; Evaluation Studies as Topic ; Gallbladder Diseases - enzymology ; Gastrointestinal Diseases - enzymology ; Gastrointestinal Neoplasms - enzymology ; Humans ; Liver - enzymology ; Liver Diseases - diagnosis ; Liver Diseases - enzymology ; Methods ; Peptic Ulcer - enzymology ; Phenylalanine - pharmacology ; Urea - pharmacology ; Urologic Diseases - enzymology</subject><ispartof>Clinica chimica acta, 1974-06, Vol.53 (3), p.291-297</ispartof><rights>1974</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0009898174902678$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4847104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerhardt, W.</creatorcontrib><creatorcontrib>Nielsen, M.Lykkegaard</creatorcontrib><creatorcontrib>Nielsen, O.Vagn</creatorcontrib><creatorcontrib>Olsen, J.S.</creatorcontrib><creatorcontrib>Statland, B.E.</creatorcontrib><title>Clinical evaluation of routine measurement of liver and bone alkaline phosphatases in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Determination of liver and bone alkaline phosphatase in human serum was carried out with a recently developed routine method using differential inhibition by
l-phenylalanine and carbamide on the LKB 8600.
Three groups of patients were investigated: 71 patients with hepato-biliary disorders, 22 patients with bone diseases, and 67 patients without recognizable hepato-biliary or bone diseases.
Agreement between the clinical diagnosis and the separate values of liver AP and bone AP was found in patients with elevated total alkaline phosphatase activities in serum.</description><subject>Alkaline Phosphatase - antagonists & inhibitors</subject><subject>Alkaline Phosphatase - blood</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Autoanalysis</subject><subject>Bone and Bones - enzymology</subject><subject>Bone Diseases - diagnosis</subject><subject>Bone Diseases - enzymology</subject><subject>Colitis, Ulcerative - enzymology</subject><subject>Evaluation Studies as Topic</subject><subject>Gallbladder Diseases - enzymology</subject><subject>Gastrointestinal Diseases - enzymology</subject><subject>Gastrointestinal Neoplasms - enzymology</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Liver Diseases - diagnosis</subject><subject>Liver Diseases - enzymology</subject><subject>Methods</subject><subject>Peptic Ulcer - enzymology</subject><subject>Phenylalanine - pharmacology</subject><subject>Urea - pharmacology</subject><subject>Urologic Diseases - enzymology</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU2O1DAQhS0EGpqBG4DkFZpZBOzESWwWI0HzK1piA2ur4lQUg-MEO2mpuSG3wu5psbJc9fm9cj1CnnP2ijPevGaMqUIqyW9acatY2bSFfEB2XLZVUQlVPiS7_8hj8iTGn-kqWMOvyJWQouVM7MjfvbPeGnAUj-A2WO3s6TzQMG-r9UgnhLgFnNCvuezsEQMF39NuTl1wv8BlbBnnuIywQsRIrafjNoGnEcM2vaHv7TBgSAo22Vg_2s6ebboTdcUyoj85cOCzTlY2EDqYbI_0JjnDLU3oOiI9fH1HZcMYTUVzFgiw5ifgTn8wPCWPBnARn13Oa_Lj44fv-8_F4dunL_u3hwLLhq9FrQbFTSfa2rC8harjda3YgIOpRCOaupGqUwZKI_nAmcKurYRQtWmqtuayrK7Jy3vdJcy_N4yrnmw06NIPcN6ilmXCK5XBFxdw6ybs9RLsBOGkL7tP_bv7PqZpjxaDjsaiN9jbgGbV_Ww1ZzpnrXOQOgepW6HPWWtZ_QPFvp0f</recordid><startdate>19740628</startdate><enddate>19740628</enddate><creator>Gerhardt, W.</creator><creator>Nielsen, M.Lykkegaard</creator><creator>Nielsen, O.Vagn</creator><creator>Olsen, J.S.</creator><creator>Statland, B.E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19740628</creationdate><title>Clinical evaluation of routine measurement of liver and bone alkaline phosphatases in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer</title><author>Gerhardt, W. ; 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l-phenylalanine and carbamide on the LKB 8600.
Three groups of patients were investigated: 71 patients with hepato-biliary disorders, 22 patients with bone diseases, and 67 patients without recognizable hepato-biliary or bone diseases.
Agreement between the clinical diagnosis and the separate values of liver AP and bone AP was found in patients with elevated total alkaline phosphatase activities in serum.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4847104</pmid><doi>10.1016/0009-8981(74)90267-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 1974-06, Vol.53 (3), p.291-297 |
| issn | 0009-8981 1873-3492 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_82449392 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alkaline Phosphatase - antagonists & inhibitors Alkaline Phosphatase - blood Alkaline Phosphatase - metabolism Autoanalysis Bone and Bones - enzymology Bone Diseases - diagnosis Bone Diseases - enzymology Colitis, Ulcerative - enzymology Evaluation Studies as Topic Gallbladder Diseases - enzymology Gastrointestinal Diseases - enzymology Gastrointestinal Neoplasms - enzymology Humans Liver - enzymology Liver Diseases - diagnosis Liver Diseases - enzymology Methods Peptic Ulcer - enzymology Phenylalanine - pharmacology Urea - pharmacology Urologic Diseases - enzymology |
| title | Clinical evaluation of routine measurement of liver and bone alkaline phosphatases in human serum: Differential inhibition by l-phenylalanine and carbamide (urea) on the LKB 8600 reaction rate analyzer |
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