A receptor mediating sexual differentiation?

SEXUAL differentiation of the brain is believed to be mediated by exposure to testicular androgens at a critical period of development—prenatal in most species, but during the first 5 d after birth in rats. Only those androgens which are potential substrates for aromatising enzymes (that is, those w...

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Veröffentlicht in:	Nature (London) 1974-11, Vol.252 (5480), p.259-260
Hauptverfasser:	BARLEY, JACKIE, GINSBURG, M., GREENSTEIN, B. D., MACLUSKY, N. J., THOMAS, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - metabolism Animals Binding, Competitive Brain - metabolism Brain - ultrastructure Cerebral Cortex - metabolism Cytosol - metabolism Estradiol - metabolism Estradiol Congeners - metabolism Female Humanities and Social Sciences Hypothalamus - metabolism letter Male multidisciplinary Rats Receptors, Cell Surface Science Science (multidisciplinary) Sex Characteristics Tritium
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Beschreibung
Zusammenfassung:	SEXUAL differentiation of the brain is believed to be mediated by exposure to testicular androgens at a critical period of development—prenatal in most species, but during the first 5 d after birth in rats. Only those androgens which are potential substrates for aromatising enzymes (that is, those which can be converted to oestrogens in vivo ) are effective 1–4 . These observations led to the concept that masculinisation of the brain is caused by local conversion of androgens to oestrogens.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/252259a0