Human Muscular Dystrophy as an Aberration of the Connective Tissue

THE pathological changes in the muscle in human muscular dystrophy have been well characterized. They consist of great diversity of muscle fibre size, increase in number of sarcolemmal nuclei (which may take the form of chains situated centrally in the fibre), and atrophy of the fibres. Although it...

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Veröffentlicht in:	Nature (London) 1959-06, Vol.183 (4677), p.1741-1743
Hauptverfasser:	BOURNE, GEOFFREY H., GOLARZ, M. NELLY
Format:	Artikel
Sprache:	eng
Schlagworte:	Connective Tissue - pathology Humanities and Social Sciences Humans letter multidisciplinary Muscular Dystrophies - pathology Old Medline Science Science (multidisciplinary)
Online-Zugang:	Volltext
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Zusammenfassung:	THE pathological changes in the muscle in human muscular dystrophy have been well characterized. They consist of great diversity of muscle fibre size, increase in number of sarcolemmal nuclei (which may take the form of chains situated centrally in the fibre), and atrophy of the fibres. Although it has been said 1 that phagocytosis of degenerating fibres is rare, we have found evidence in a number of cases of what appears to be invasion and destruction of muscle fibres by elements of connective tissue.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/1831741a0