The IgG Receptor Induced by Herpes Simplex Virus: studies using Radioiodinated IgG

The IgG Receptor Induced by Herpes Simplex Virus: studies using Radioiodinated IgG

Sir William Dunn School of Pathology, Oxford University, Oxford, England Further evidence is presented that the receptor induced on the surface of cells infected with herpes simplex virus is specific for the Fc fragment of the IgG molecule of several species. A method has been developed for quantita...

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Veröffentlicht in:Journal of general virology 1974-07, Vol.24 (1), p.167-178
Hauptverfasser: Westmoreland, Diana, Watkins, J. F
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites, Antibody
Cell Line
Cell Membrane - immunology
Cricetinae
Epithelial Cells
Erythrocytes - immunology
Fibroblasts
Haplorhini
HeLa Cells
Hemadsorption
Horses - immunology
Humans
Immune Sera
Immunoglobulin G
In Vitro Techniques
Iodine Radioisotopes
Kidney
Mice
Rabbits - immunology
Sheep - immunology
Simplexvirus - growth & development
Simplexvirus - immunology
Virus Replication
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Zusammenfassung:Sir William Dunn School of Pathology, Oxford University, Oxford, England Further evidence is presented that the receptor induced on the surface of cells infected with herpes simplex virus is specific for the Fc fragment of the IgG molecule of several species. A method has been developed for quantitative studies of this receptor using rabbit IgG labelled with [ 125 I]. The effects of actinomycin D, puromycin, and cytosine arabinoside on the development of the receptor during the virus growth cycle are described. Evidence was obtained of a turnover of membrane receptors after infection. Received 30 January 1974; accepted 1 March 1974.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-24-1-167